Main Article Content
Abstract
The test presented here is based upon the proband and his/her affected as well as unaffected siblings. Here, the siblings are analyzed in terms of similarities of haplotypes. The proposed ‘S’ test is used in testing hypothesis that a particular disease has random pattern of inheritance against the alternative hypothesis that it has non-random pattern of inheritance. Probability distribution, mean and variance of the test are derived under the null hypothesis of random inheritance of the disease. It is then applied to data set of varying size of sibships having at least one affected and one unaffected sibs to investigate the existence of linkage disequilibrium.
Article Details
Authors who publish with this journal agree to the following License
CC BY: This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
How to Cite
Khattak, M., Shah, S., & Din, S. (2007). Test S of Haplotype Concordance and Discordance . Pakistan Journal of Statistics and Operation Research, 3(1), 45-52. https://doi.org/10.18187/pjsor.v3i1.76
